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They arise when executive leadership, governance structures, and QMS maturity fail to treat electronic data as regulated evidence requiring technical restriction, independent oversight, and lifecycle control

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Alternatively, if cannabinoids are able to reduce the opening of hemichannels during a chronic inflammatory event, it may subsequently prevent excitotoxicity caused by excess glutamate and reduce the release of pro-inflammatory cytokines, thus maintaining neuronal and astrocyte viability (Froger et al., 2009