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This targeted approach attempts to minimize damaging signaling while preserving other host defenses

Animal Early human IBD/ulcerative-colitis trials of BPC-157 (PL-14736) reported it as safe with no reported toxicity but these clinical trials were not completed or fully published

The indirect costs of IC/BPS, including time away from work and lost productivity while working, are particularly significant since the condition primarily affects working age adults, and especially women aged 25-50 years

[iv] Challenges Associated With FIH Trials Since these studies represent the first administration of an investigational drug in humans, they are associated with inherent challenges, especially safety