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If you are more active or focused on building or maintaining significant muscle, aim closer to 1.0

The most important benefit, in the case of gut health, is that the gelatin in bone broth helps to seal the junctions in the intestines so they are no longer permeable, and those pesky foreign invaders can no longer pass through the intestinal wall and inflame the immune system

In DCM, upregulation of the copper importer SLC31A1 makes patients exceptionally sensitive to chelators, whereby a standard dose can precipitate severe deficiency [240]

Gastrointestinal side effects such as nausea, vomiting, and diarrhoea can lead to fluid and electrolyte losses, potentially triggering muscle cramps