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10.3389/fendo.2020.558874 Front Endocrinol

The SGRQ consists of 50 items that yield a Total score (effect of disease on overall HRQoL) based on a sum of the total number of items, as well as 3 component scores: Symptoms (frequency and severity of respiratory symptoms), Activity (disturbance or limitations to daily physical activities), and Impacts (psychosocial function disturbances due to airway disease)

The disruption of this network produces organelle-specific imbalances that propagate into cellular dysfunction and contribute to a wide spectrum of human diseases, including neurodegeneration, cancer, metabolic disease and developmental disorders

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