compound semaglutide vs tirzepatide Efficacy of 5, 10 and 15 mg versus 2 mg in patients with type 2 diabetes: An adjusted indirect treatment comparison compounded semaglutide tirzepatide reliable sources

A major real-world study published in early 2026 led by researchers at Johns Hopkins Bloomberg School of Public Health and analysing electronic health records from approximately 175,000 people with T1D in the US found that those taking GLP-1 drugs had a roughly 15% lower five-year risk of major cardiovascular events and a 19% lower risk of end-stage kidney disease, without any increase in hospitalisation for DKA or severe hypoglycemia

References Wilding JPH et al

[PubMed: 10501818] 674

If youre taking birth control pills either the combined pill or the progestogen-only pill (mini-pill) Mounjaro can reduce their effectiveness