surmount trials tirzepatide ESC 2025: post-hoc SURMOUNT-5 data affirms tirzepatide's lead in CVD risk reduction For the first time, tirzepatide

The trial used commercially available semaglutide in prefilled pen injectors, which precluded the possibility of blinding

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Practical strategies when appetite is suppressed: Prioritize protein at every meal, even if portions are small Consider a protein shake between meals rather than trying to fit everything into three sittings Choose protein-dense foods that dont require huge volumes Track your intake for a week to see where you actually land (most people underestimate) If weight management is your primary goal, understanding how to support your metabolism throughout this process makes all the difference

Johnston KL, Clifford MN, Morgan LM