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A higher pre-drug urinary level of the compound taurine was associated with a lower degree of hepatotoxicity, whereas a higher pre-drug level of trimethylamine-N-oxide and betaine was associated with a greater severity of liver damage

The redox imbalance is more likely induced by the net effect of low antioxidative defense systems and thus constantly produces endogenous RONS, such as angiotensin II, lipoxygenase, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and myeloperoxidase [19]

After an initial loading phase, some patients maintain with monthly injections

3), including H-bonds with the backbone of S129 ECD , and hydrophobic interactions with D77 ECD , G78 ECD , W79 ECD , Y131 ECD and W128 ECD , consistent with interactions also formed by Pro32 of sCT