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Some subjects may be better candidates for long-term research than others based on their personal risk profiles

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10 Interventions to increase tissue GSH concentrations have used GSH itself, monoesters that are more completely absorbed, or alternative precursors

Those in the higher arms were begun at a lower amount and stepped up at four-week intervals until they reached their assigned arm, and the protocol deliberately tested two different starting amounts within the 4 mg and 8 mg arms to compare how escalation pace affected tolerability