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Somewhat unexpectedly, markers deduced from dementia only partially overlap with amino acid markers obtained from frailty patients with cognitive defects (16), so that frailty and dementia partly share the diminished cognitive markers

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QgZ: Writing original draft, Data curation, Formal Analysis, Validation

While the BBB serves as a barrier to restrict the passage of molecules, the integrity and function of the BBB can be compromised by disease states, disease-caused inflammation, and immune responses in the brain [1, 3, 9], or even systemic infection and inflammation [10] resulting in BBB disruption and greater BBB penetration [11]