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A systematic review by Horton (2000) in the American Journal of Tropical Medicine and Hygiene found that albendazole-associated hepatotoxicity occurred in approximately 1-5% of patients receiving prolonged high-dose therapy for echinococcosis (hydatid disease), but was rare at standard short-course antiparasitic doses

Previous research by this group showed that infusing normal fetal sheep with a high dose (6.6 gkgh) of IGF-1 LR3, an analog for IGF-1, increased body weight while simultaneously reducing insulin levels and GSIS

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Concurrently, K326 forms hydrogen bonds with the peptide backbone at positions +2, +4 and +1 for the Ent5.1, Apl2.1 and Yap1801 complexes