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Importantly, microbiota changes observed during GLP-1 RA therapy may be influenced by confounding factors such as weight loss magnitude, dietary modifications, and concomitant treatments, particularly metformin

suggests that multiple amino acid substitutions are introduced to support the peptides stability against enzymatic degradation potentially: (1) Position 2 (Alanine D-Alanine): Introduces a D-form amino acid, which is less susceptible to standard enzymatic breakdown

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