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SUSTAIN 4 and SUSTAIN FORTE were only powered to detect differences in A1C from baseline to Week 30 and Week 40, respectively

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79 The role of RWS has also been recognized by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), that have provided guidelines for the use of RWS to support regulatory decision-making for medical treatments and devices ( www.fda.gov and )

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Melanotan 2 is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (-MSH)

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Avg weight loss (72 weeks): ~15% (SURMOUNT-1) 10 mg Weeks 1316 The most common maintenance dose

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