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Materials and methods Participants and procedures In this case-control study, 28 treatment-seeking individuals diagnosed with CUD and 38 healthy controls were recruited on a voluntary basis in April and May 2023 at the Psychiatric Clinic in SS Annunziata Hospital, Chieti, Italy

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Thus, FOXO4-DRI actually is most effective against senescent cells expressing high levels of SASP and could as such be particularly effective against loss of renal function