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Notably, the specific composition of membrane phospholipids, particularly the levels of phosphatidylethanolamine (PE) containing polyunsaturated fatty acids (PE-PUFAs), plays a crucial role in determining ferroptosis sensitivity (Kagan et al., 2017)

Additionally, it increases the levels of ferroptosis markers (e.g., Slc7a11 and Gpx4), which predispose PDAC cells to ferroptosis under conditions of Gln deprivation, thereby providing a combined strategy for PDAC therapy (49)