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Keloid Senescent Fibroblast Elimination & SASP Suppression (Communications Biology, 2025) FOXO4-DRI Induces p53-pS15 Nuclear Exclusion and Apoptosis in Keloid Fibroblast Models A study published in Communications Biology (Nature Publishing Group, 2025) used single-cell RNA sequencing to characterise the senescent cell landscape in keloids pathological scars with tumour-like aggressiveness

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However, the levels detected were low, which is explained by the fact that human FcRn binds poorly to mouse IgG antibodies, resulting in rapid intracellular degradation 31,56 of the generated antibodies