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The pivotal SURMOUNT-1 trial showed 15 to 22 percent mean body weight loss over 72 weeks at therapeutic doses

For perimenopause specifically, hormonal fluctuation drives many of the most disruptive symptoms estrogen can spike and crash erratically, which is why some patients feel worse in early perimenopause than in full menopause

Comment: A few commenters supported the proposal to adopt the Public Health Reporting Using TEFCA measure as an optional bonus measure, but expressed concern that the limited TEFCA adoption among PHAs may prevent many MIPS eligible clinicians from reporting the measure and attaining bonus points

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