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For drugmakers, the news reinforces the need for a more focused pipeline strategy, optimizing and expanding in areas where GLP-1s are already validated, like weight management, cardiovascular risk reduction, and liver disease

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They may develop nutrient deficiencies, hormone disruptions, and elevated stress levels, all of which can negatively affect fertility

2.3.2 Gut microbiota and its metabolites modulate GLP-1 secretion Emerging evidence highlights a bidirectional regulatory interplay between the gut microbiota and GLP-1, whereby microbial composition and metabolites exert profound influences on GLP-1 synthesis, secretion, and signaling