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These hormones naturally slow digestion and signal fullness, which is why most side effects involve the gastrointestinal system

GIP is another hormone involved in insulin release and glucose regulation, so targeting both pathways could create a stronger effect on satiety and blood sugar management compared to GLP-1 alone

What causes it and how to help quiet it, according to experts - CBS News, accessed April 22, 2025, Understanding Food Noise and How GLP-1 Medications Help Silence It - Flow Wellness, accessed April 22, 2025, GLP-1 Receptor Agonists and Related Mental Health Issues

GLP-1R activation suppresses appetite, slows gastric emptying, and stimulates glucose-dependent insulin secretion