Dysbiosis of the gut microbiota is now recognized as a critical factor in both the initiation and progression of IBD ( 5-Aminosalicylic acid (5-ASA) remains a cornerstone of IBD therapy ( Natural polysaccharides have demonstrated considerable benefits in IBD treatment, as they reduce drug-related side effects while enhancing therapeutic efficacy ( Additionally, polysaccharide-based nanoparticles have attracted attention for their ability to improve drug stability and sustain therapeutic activity ( 2 The relationship between the intestinal microbiome and IBD Numerous studies have documented significant alterations in the intestinal microbiota of patients with IBD compared with healthy individuals ( For example, one study reported markedly reduced levels of anti-inflammatory taxa such as Faecalibacterium prausnitzii , Bifidobacterium adolescentis , and other beneficial species in CD patients, alongside a significant increase in the pro-inflammatory species Ruminococcus gnavus ( Shigella , Aeromonas , Clostridium , Sutterella , and Akkermansia muciniphila
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The same shuttling system can also export excess acetylcarnitine out of the mitochondria to limit inhibition of pyruvate dehydrogenase and spare the pool of free CoA necessary for other molecules
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