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These findings further support the role of human-relevant platforms, such as genoskin skin models, in generating predictive data earlier in development while helping reduce reliance on animal testing

That said, hormonal evaluation should still precede any PT-141 prescription to rule out treatable causes

For comparison, in the table below, we also show those GLP-1 agonists with active ingredients only approved for treatment of diabetes that have less potential for off-label weight loss use (Bydureon BCise, Trulicity)

While injectable incretin therapies have been transformative, obesity is a chronic disease that demands effective, long-term management strategies