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Alpha cells as a source of cholinergic signals in human islets Rodent islets are richly innervated by sympathetic and parasympathetic fibres, and signals from the autonomous nervous system play an important role in the maintenance of proper GSIS from pancreatic beta cells [52, 53]

In the past few years, several GLP-1 drugs have shown dramatic weight-loss effects, not only controlling blood glucose but also shrinking adipose tissue