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Among them, the most typical is the chemokine Leukotriene B4 (LTB4), the increased expression of which causes recruitment of neutrophils, ATMs, T cells, and B cells, which increase expression of pro-inflammatory cytokines, eventually leading to the development of eWAT inflammation and obesity (132) ( Figure 3 )

Discussing which patients may benefit most from the drug if approved in the future, Dr Kovil said retatrutide could become especially important for people with severe or morbid obesity who require very large reductions in body weight

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