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Dihexa (PNB-0408) is a synthetic oligopeptide derived from angiotensin IV, developed at Washington State University in the laboratory of Dr Joseph Harding

A controlled study (PMID: 7777652) found that DSIP did not significantly affect CRH- or meal-induced ACTH and cortisol secretionindicating DSIP does not measurably blunt the human cortisol response, contrary to stress-protective effects suggested by some animal studies

However, in patients with pernicious anaemia or malabsorption, these stores cannot be replenished through diet, making regular injections essential