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Trp53 fl/fl (AKP) mice 72 h post-tamoxifen intraperitoneal (i.p.) injection and cultured in 3D as previously reported (Extended Data Fig

3.2 Arrhythmia analysis Separate data-analyses were estimated according to the type of adverse event arrhythmia disclosed, homogeneity of included studies was good for all events, with the following results:atrial fibrillation ( I 2 = 44%, p =0.08), atrial flutter ( I 2 = 0%, p =0.49), ventricular fibrillation ( I 2 = 0%, p =0.86), ventricular tachycardia ( I 2 = 0%, p =0.42), atrial tachycardia ( I 2 = 0%, p =0.45), sinus node ( I 2 = 0%, p =0.54), ventricular precontraction ( I 2 = 0%, p =0.64), second degree AV block ( I 2 = 0%, p =0.84), and complete AV block ( I 2 = 40%, p =0.13), so a fixed-effect model was used to combine effect sizes

Both NAD+ precursors (such as NMN and NR) and NAC are generally considered safe for most people when taken at recommended doses

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