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We found obviously cardiac mitophagy dysfunction and LVH in TAC group, compared to that in Sham group, and the cardiac mitophagy dysfunction and LVH induced by pressure overload were significantly improved by semaglutide

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10.1016/s0168-9525(01)02616-6 Trends Genet 51 YoonD

Accumulation may occur in patients with severe renal impairment who are not receiving dialysis, necessitating careful monitoring