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Semaglutide Brand-Name Options: Wegovy (Weight Loss Approval): Approved For: Chronic weight management Dosing: Once-weekly injection, up to 2.4 mg Cost: $1,349/month without insurance Availability: Periodic shortages Ozempic (Diabetes Approval): Approved For: Type 2 diabetes Dosing: Once-weekly injection, up to 2.0 mg Cost: $969/month without insurance Often prescribed off-label for weight loss Compounded Semaglutide: The Most Affordable Option: Cost: $199-$599/month (TrimRx: $199/month) Same active ingredient as Wegovy/Ozempic Available through telehealth platforms Better availability than brand-name options Cost Comparison: Tirzepatide vs Semaglutide: When to Choose Semaglutide Over Tirzepatide: Budget is Primary Concern: Compounded semaglutide at $199/month costs $150/month less than compounded tirzepatide ($349/month)

Gastrointestinal symptoms dominate the side effect profile because GLP-1 receptors are concentrated in the digestive tract and brain appetite centers, not respiratory tissues

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