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Administration of a recombinant adenovirus producing GLP-1 (4 10 9 PFU/mouse) to ob/ob mice reduced the macrophage population and production of TNF- , MCP-1, and IL-6 in adipose tissue via inhibition of nuclear factor-kappa B (NF- B) activation and phosphorylation of ERK1/2 and c-Jun N-terminal kinases [18]

68 In contrast, other large-scale population-based studies have failed to demonstrate a significant increase in intestinal obstruction risk when GLP-1 RAs were compared with SGLT-2 inhibitors

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You think youre large for your whole life and you look [back] and youre like, 'I was fit.' Yeah, I had big muscles