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Glucagon like peptide 1 based therapies for the treatment of type 2 diabetes mellitus

Alanine substitutions in Y186 1.47b and K231 2.67b had a moderate effect (416 fold) on GLP-2 potency (Fig

These agents improve glycemic control, promote weight loss, lower blood pressure, and may reduce systemic inflammation and endothelial dysfunction [36,37,38,39]