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Mantel , Holmqvist M, Andersson Dea, Andersson DC et al (2017) Association between rheumatoid arthritis and risk of ischemic and nonischemic heart failure

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Conversely, CHAC1s role in ferroptosis makes it a potential biomarker and therapeutic target, with studies indicating that its modulation could be leveraged to induce ferroptosis selectively in breast cancer cells, thereby suppressing tumor proliferation and improving patient outcomes