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Certain overgrown pathogenic bacteria produce high levels of their own rogue protease enzymes
FP reports the receipt of grants/research support from AstraZeneca, Eisai, and Roche, and receipts of honoraria or consultation fees from Amgen, AstraZeneca, Daichii Sankyo, Celgene, Eisai, Eli Lilly, Exact Sciences, Gilead, Ipsen, Italfarmaco, Menarini, MSD, Novartis, Pierre Fabre, Pfizer, Roche, Seagen, Takeda, and Viatris, all outside the submitted work
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This is largely due to their high sensitivity (0.90) but low specificity (0.20), which leads to a substantial number of unnecessary biopsies, as reported in reviews included in clinical practice guidelines
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