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2020;11:e00722-20

However, macrophages in aged organisms exhibit several functional impairments, which contribute to a weakened immune system and increased susceptibility to inflammation and infection

More than 20 products based on ASOs, aptamers, siRNA, and mRNA have been approved for marketing to treat various rare genetic disorders (Table 1)

At species level, the downregulation of the hexitol fermentation to lactate, formate, ethanol and acetate pathway was mainly due to Lactobacillus salivarius , with a significant decrease in T2 and T4 compared to T1, whilst the stachyose degradation pathway was down regulated in L