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In this regard, specific activation of GLP-1R in this region decreases food intake [163], the intra-LH microinjection of Ex-4 reduces food-motivated behavior, and knocking down the GLP-1R increases food reinforcement and body weight [242]

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Practically, BPC-157's gut-healing properties may help counteract the severe nausea often caused by GLP-1s, and its tissue-protective effects may help mitigate the muscle loss associated with rapid weight reduction