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Excessive Ca 2+ entry into the cytosol leads to pericyte calcium overload and contraction, causing microvascular constriction

Its also important for the mothers health during pregnancy

Lancet 397(10278):971984 Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D et al (2023) Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial