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This article was authored by Sina Rashedi, MD, MPH , Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

These insights have not only enhanced our understanding of CHD pathophysiology but have also established a theoretical foundation for developing ferroptosis-targeted therapeutic strategies

Our studies show that, among several matrix components, only collagen type I is significantly enhanced by the action of LOX/BMP1, an observation that is consistent with its prominent role in the ECM as primary substrate for these collagen-modifying enzymes 22,23

Cost considerations also favor micro-dosing for long-term management