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14.2 Weight Reduction and Long-term Maintenance Studies in Adults with Obesity or Overweight Overview of Clinical Trials in Adults The efficacy of WEGOVY once weekly subcutaneous injection for weight reduction and long-term maintenance of body weight in conjunction with a reduced-calorie diet and increased physical activity were studied in three 68-week, randomized, double-blind, placebo-controlled trials

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Non-drug interventions such as bariatric surgery and lifestyle changes also serve as alternatives