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Moreover, in attempts to replace the hydroxyl group of the tyrosine moiety to avoid potential problems with phase II metabolism compound 27 was prepared ( 27 ) is 10-fold less potent than 25 demonstrating that interactions with the hydroxyl group is important, although not critical for activity
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According to a double-blind placebo-controlled clinical trial by the National Institute of Health [1], Glutathione treatment has proven to significantly lower the skin melanin index of study participants, after a few weeks of use
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