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Final Thoughts on When to Take Vitamin B12 To truly feel the energy-enhancing, brain-boosting, and metabolism-supporting benefits of vitamin B12, morning is the optimal time to take it

Where to Give B12 Shot Intramuscular injections can be given in several locations on the body, with the most common being the upper buttocks, the shoulder, and the thigh

Patches absorb slowly through the skin, so they work better for mild support rather than treating serious deficiency

The cost can vary, but around $25 a shot is a common price point, though this can differ based on your location and whether you have insurance coverage