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Accessed July 24, 2022.

Users report several physical factors that may contribute to libido changes: Energy Levels: The caloric restriction and appetite suppression can lead to reduced energy, potentially affecting sexual desire [11] Digestive Effects: Common side effects like nausea and gastrointestinal discomfort may impact sexual interest Blood Flow Changes: The medication's effects on vascular function might influence sexual response, particularly in reproductive tissues Research suggests these effects vary among individuals, with some experiencing improvements in sexual function due to better metabolic health, while others report decreased libido

A major real-world study published in early 2026 led by researchers at Johns Hopkins Bloomberg School of Public Health and analysing electronic health records from approximately 175,000 people with T1D in the US found that those taking GLP-1 drugs had a roughly 15% lower five-year risk of major cardiovascular events and a 19% lower risk of end-stage kidney disease, without any increase in hospitalisation for DKA or severe hypoglycemia

Constipation is a common but manageable Ozempic side effect, affecting about 35% of users