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A Clear Medical Answer Share If you have hypothyroidism, you might wonder: Can I safely take GLP-1 medications like semaglutide, liraglutide, or tirzepatide

Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds

Louis Aronne, director of the Comprehensive Weight Control Center and the Sanford I

This pairing is widely studied for its ability to mimic the bodys natural pulsatile GH secretion, producing synergistic and physiologically balanced effects on growth hormone and IGF-1 output without significant influence on cortisol or prolactin levels