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Consistently, NAC and cysteine have also been shown to enhance Cu 2+ reduction and copper-induced proteotoxic stress, 168 suggesting that thiol-rich reducing environments can, under specific conditions, contribute to cytotoxicity

11 Using healthy patients as a control, studies in patients dying from PD have observed 40% reduced glutathione levels in these patients, whereas oxidized glutathione was insignificantly marginally elevated

Previous efforts using cerium oxide nanoparticles and other inorganic platforms demonstrated commendable antioxidant capabilities but often lacked robust targeting mechanisms or detailed mechanistic insight ( While these findings are promising, several considerations merit further inquiry

Kuter DJ, Bussel JB, Lyons RM, et al