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[7] [8] However, during other metabolic activities, NAD+ is consumed by NAD+-dependent enzymes and may subsequently become depleted over time, contributing to increased DNA damage, age-related illnesses and diseases, and mitochondrial malfunction

It is important to distinguish between excessive supplementation and pathologically elevated B12 levels, which may indicate underlying haematological disorders, liver disease, or renal impairment rather than true overdose

Cobalequin made by Nutramax is a cyanocobalamin chewable tablet supplement formulated for dogs and cats, that comes in a 250 microgram size

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