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7 Future research directions Despite remarkable advances in understanding the reproductive toxicity of environmental endocrine disruptors, fundamental knowledge gaps continue to impede comprehensive risk assessment and effective intervention development

53 In a phase 2 randomized, double-blind trial, weekly injections of retatrutide (1 mg12 mg) led to weight reductions of 7.217.5% at 24 weeks and 8.724.2% at 48 weeks in individuals with obesity or pre-obesity (without diabetes), compared to 1.6% and 2.1% with placebo, respectively, showing no plateau in this period (Table 2)

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For both species, the HAE technique in combination with ethanol resulted in extracts with significantly higher antidiabetic activity