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One of the primary players, as mentioned, is the VEGF pathway

Clinical and Hematological Characteristics of Vitamin B12 Deficiency and Evaluation of the Therapeutic Response to Vitamin B12 Supplementation

Research indicates that approximately 80% of individuals with hypothyroidism have Hashimoto's anti bodies, but this statistic can vary based on environmental factors and individual health conditions

These include genetic, oxidative stress, autoimmune, autoinflammatory, neural, apoptotic, molecular adhesion disorder and multifactorial mechanisms [1]