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Vitamin D: deficiency blunts the response to peptide therapy and mimics fatigue that patients might otherwise attribute to the protocol

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In vivo oral administration of AESN notably elevated antioxidant levels, reduced peripheral corneal vascularization and minimized structural damage, including corneal epithelial loss and iridocorneal angle narrowing

and PI3K/Akt-induced accumulation of the proto-oncogene -catenin, via inactivation of its inhibitor glycogen synthase kinase 3 (GSK3) (5, 14, 20) ( Figure 2 )