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Additionally, for ebselen to become a clinically acceptable radioprotector, there is also a need for establishing its selective radioprotective effects without compromising the tumor radiosensitivity

Different NADPH subunits were detected by Western blot analysis (Fig

A 2014 mouse study found that NAC and vitamin E accelerated lung tumor progression and reduced survival.41 A 2015 melanoma mouse study found that NAC increased lymph node metastases in mice with malignant melanoma.42 A 2019 mouse study reported that NAC protected against emphysema-related lung damage but also induced lung adenocarcinoma in some mice.43 And a 2021 hepatocellular carcinoma study found that antioxidant supplements including NAC promoted tumor formation, growth, and drug resistance in experimental models by reducing intracellular ROS.3 Newer human data add another layer of complexity

Quantification of glutathione concentration Assays were performed on brain tissue and plasma samples using the GSSG/GSH Quantification Kit (Dojindo, Kumamoto, Japan )