The key difference lies in receptor targeting: Semaglutide GLP-1 receptor only Tirzepatide GLP-1 + GIP receptors Retatrutide GLP-1 + GIP + glucagon receptors The addition of glucagon receptor activity introduces a potential energy-expenditure component compared with GLP-1-only compounds
To view a copy of this licence, visit About this article Cite this article Zhu, X., Zhang, C., Feng, S
"Maximizing the nutritional value of every bite is especially important when GLP-1 medications reduce your appetite," says Manaker
If you experience low mood, thoughts of self-harm, or suicidal thoughts, seek urgent medical help contact your GP, call NHS 111, or in an emergency call 999 Patients are encouraged to ask their doctor about the current evidence base, the distinction between trial data and licensed use, and what support will be available if side effects occur