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The coexistence of both diseases not only induced a systemic pro-inflammatory state leading to coronary microvascular endothelial inflammation and resulting in myocardial dysfunction, but also induced a persistent pro-inflammatory state causing cardiac fibrosis that led to myocardial necrosis [7,8,9,10]

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doi: 10.1016/S0140-6736(09)60659-0 16 BuseJBBergenstalRMGlassLCHeilmannCRLewisMSKwanAYet al

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