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B vitamin therapy is beneficial in patients with good renal function, but harmful in patients with significantly impaired renal function

These effects occur through mechanisms including enhanced angiogenesis, modulation of growth factor expression, and direct cytoprotection of gastric epithelial cells

[6] [65] Since there are few non-animal sources of the vitamin, vegans are advised to consume a dietary supplement or fortified foods for B 12 intake, or risk serious health consequences