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Aging alters the circadian system, particularly melatonin secretion, amplitude, and receptor sensitivity, and these changes affect sleep architecture, metabolism, and cognitive function

Plasma stability and protein binding Plasma stability studies on BPC-157 have suggested it is notably resistant to rapid proteolytic degradation in serum a feature that may contribute to the observed effect durability

Further investigation of stabilization of the thiol group could be possible for further development as a solution, though oxygenation may be an issue with products used continuously over a month

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