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Declaration of interest G.M.J.T

In addition, during tIRI, p53 induces sustained expression of the gene Tigar , leading to the failure to convert glycolysis to the pentose phosphate pathway, resulting in testicular germ cell apoptosis ( 5 Potential therapeutic agents affecting the p53-related pathways in male infertility Recently, efforts have been made to develop p53-targeted therapies for certain diseases, such as cancer and neuroinflammation (138, 139)

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